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Katherine Lawless

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Vitamin D deficiency: the new link to type 2 diabetes mellitus in United Arab Emirates

Posted by Katherine Lawless on Thu, Apr 11, 2019 @ 14:04 PM

“Diabetes is the fastest growing debilitating disease in the world”.

Dr. Al-Anouti and Dr. Al-Safar

In 2015, statistics showed that 415 million people suffer from diabetes worldwide. The rate is expected to increase by 54.5% and reach about 642 million people by 2040.[1] The Middle Eastern population account for approximately 20% of these cases. According to the International Diabetes Federation (IDF), the United Arabian Emirates (UAE) has 745,940 diabetics, 304,000 undiagnosed diabetics, and 934,300 pre-diabetics.3 We corresponded with researchers Dr. Al-Anouti and Dr. Al-Safar from Zayed University and Khalifa University to discuss their research on vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus.  

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Tags: DNA saliva, genetic research, Oragene RNA

Genome-wide DNA methylation comparison: Brain tissue vs. blood, saliva and buccal cells

Posted by Katherine Lawless on Wed, Apr 03, 2019 @ 13:04 PM

DNA methylation (DNAm) has become increasingly widespread in the study of psychiatric disorders.[1] Many psychiatric epigenetic studies began to work with peripheral tissues such as blood and saliva to determine which had the best correlation with brain tissue. Researchers like Smith et al compared the DNA methylation in post-mortem tissue samples with blood and saliva and found there was a higher correlation between the brain and saliva compared to blood - DNA methylation from saliva was about 3% more likely to agree with each area of the brain regions than DNA methylation with blood.1,[2]

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Tags: DNA saliva, Oragene DNA, methylation

Celebrating influential women in genetics - International women's day

Posted by Katherine Lawless on Fri, Mar 08, 2019 @ 08:03 AM

Throughout history, women have influenced and shaped our views and knowledge of science from all disciplines, including human genomics. The research of radioactivity by Dr. Marie Curie (1867-1934), the discovery of the XY sex-determination system by Dr. Nettie Maria Stevens (1861-1912), and the co-discovery of the genetic material of life by Dr. Martha Chase (1927-2003), has shaped genomics and the influence of incredible women like these is undeniable.[1] In addition, many feel that much of the credit for modeling the structure of the DNA molecule should rightfully go to a woman named Rosalind Franklin and not Watson and Crick. These women have brought their love of genetics to life and shared their scientific discoveries with the world.

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Tags: genetic research, human genomics

Is whole genome sequencing the new first-line test for children with genetic diseases?

Posted by Katherine Lawless on Tue, Feb 19, 2019 @ 13:02 PM

Congenital anomalies and genetic disorders are the leading cause of death in children less than ten years old and affect about six percent of live births. For children with suspected genetic disorders, it is crucial to establish an early etiologic diagnosis for a prompt implementation of precision medicine and to enable optimal outcomes to guide clinical decisions. The challenge, however, is the lack of etiologic diagnosis.

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Tags: whole genome sequencing, DNA saliva cost, Oragene RNA

Oral swabs for pharmacogenomics: A comparative study of DNA quality and performance

Posted by Katherine Lawless on Tue, Feb 05, 2019 @ 13:02 PM

Pharmacogenomics is a growing field that tailors dosage and drug choices based on patient genetic profiles with the potential to benefit millions of patients with personalized medical care while changing the world of medicine as we know it. One of the key obstacles faced by those working in pharmacogenomics is DNA sample collection. Traditionally, clinicians have used blood samples for DNA collection which are costly (requiring phlebotomy and cold chain logistics) and invasive (hindering patient compliance), making the clinical integration of pharmacogenomics difficult. Many researchers are turning to the idea of buccal and/or saliva swabs as a less costly and non-invasive alternative to DNA collection. However, the question is are these sample types of high enough quality for analysis?

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Tags: DNA saliva, ORAcollect, buccal swabs

3 trends within high-impact genomics you may not know about

Posted by Katherine Lawless on Wed, Nov 28, 2018 @ 13:11 PM

Our knowledge of science is constantly changing and improving as new discoveries drive us forward in the modern world. Genomics is no exception. We witness these trends all around us either within the publications we read about new studies, in the news, or perhaps even through blogs such as this one.  For example, I recently attended the American Society of Human Genetics conference in San Diego where I picked up a copy of Cell Press’s Trends Limited Edition High-Impact Genomics, Vol. 3 (link to document) which highlights particularly impactful genomics reviews. It captured my interest and I wanted to share a few highlights with you.

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Tags: DNA saliva, human genomics

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This blog is intended to provide information to educate readers about molecular testing and genetic sample collection and DNA Genotek products.  Some of the information on this blog represents emerging scientific research or data developed for research purposes only. More information here.

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About DNA Genotek

Welcome to The Genetic Link, a blog providing new insights into DNA and RNA sample collection by DNA Genotek. DNA Genotek is a subsidiary of OraSure Technologies, Inc.

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