DNA Genotek's Sample Collection Blog

More DNA samples in less time for BRCA 1 and BRCA 2 research project

Posted by Shauna White on Thu, Jul 31, 2014 @ 13:07 PM

Obtaining DNA samples in sufficient numbers and in a timely manner can be a barrier to achieving statistical relevance for research studies. Maximizing recruitment means making sample collection easy and convenient for donors. Recently the Basser Research Center for BRCA at the University of Pennsylvania successfully used event-based collection to rapidly grow the number of participants in their research project.

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Tags: Oragene, DNA in saliva, cancer genetics, breast cancer

Need help funding a research project using DNA in saliva?

Posted by Shauna White on Tue, Oct 11, 2011 @ 10:10 AM

If you’re looking for funding for your research project using DNA in saliva, DNA Genotek’s Grant Program might be the solution. Today, DNA Genotek launched a new Grant Program designed to uncover new, innovative applications for our products. The Grant Program encompasses three primary areas of focus:

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Tags: genetic research, infectious disease, DNA in saliva, cancer genetics, personalized medicine

DNA from saliva to ID genetic variants of aggressive prostate cancer

Posted by Shauna White on Mon, Sep 19, 2011 @ 13:09 PM

At DNA Genotek, we recently learned the details of study being conducted by Wake Forest University. We wanted to share some of this information with you here on The Genetic Link. The Center for Cancer Genomics at Wake Forest University Health Sciences uses genomics to gain an understanding of the complex processes involved in the development and progression of various types of cancer, and to develop approaches to utilize this information for the prediction of cancer and personalized intervention. Dr. Xu is a Professor and the Director of the Center for Cancer Genomics at Wake Forest University. Dr. Xu is a well known genetic epidemiologist who specializes in genetic studies focused on prostate cancer. He has published about 200 papers on the genetics of cancer and other complex diseases in leading journals, including NEJM, Nature Genetics, and JNCI. 

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Tags: genetic research, DNA from saliva, DNA in saliva, cancer genetics

Epigenetic change and gene inactivation demonstrated in the saliva of a cancer patient carrying an “epimutation of MLH1”.

Posted by Megan P. Hitchins, PhD. on Wed, Jul 07, 2010 @ 16:07 PM

The Genetic Link welcomes guest blog authors. This guest submission is from Megan P. Hitchins, PhD. Medical Epigenetics Laboratory, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia. We thank Dr. Hitchins for her submission and welcome her as a guest author. I hope you enjoy this article.  

A host of familial cancer syndromes have been described in which several members of the same family develop cancer at a young age due to an inherited genetic susceptibility. It has been well established that germline mutations in the DNA sequence of genes that are protective against cancer, including tumour suppressor and DNA repair genes, are the culprit in most familial cases of cancer. Because they are inherited, these germline mutations are present in every cell of the body from conception into adulthood, knocking out one of the two copies of the protective gene. They confer a high risk of cancer development at a young age, although the cancer itself arises when the remaining normally-functioning copy of the gene is knocked out in susceptible tissues due to contributing environmental conditions, taking with it the last remnants of protection it once afforded against cancer. However, for a number of individuals with young-onset cancer, as well as entire families, the inherited defect remains unidentified, which complicates genetic counselling and clinical management of family members. Lynch syndrome is the most common of all family cancer syndromes, in which patients develop a range of cancers, the most frequent of which are colorectal and uterine cancers. Lynch syndrome is usually caused by germline mutations within one of the four genes that encode the mismatch repair system, most commonly MLH1 or MSH2. Loss of protection from the mismatch repair system results in the accumulation of mutations during cell division, and ultimately, cancer ensues. However, in about a third of Lynch syndrome patients, standard genetic screening fails to identify any pathogenic sequence change within the mismatch repair genes that might be responsible for their disease.

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Tags: DNA collection, genetics, DNA saliva, Oragene, cancer genetics, cancer research, genotyping

DNA from Saliva.... The Newest Tool in Cancer Research?

Posted by Shauna White on Tue, Mar 09, 2010 @ 11:03 AM

Recent statistics suggest cancer mortality rates are declining due to better prevention, early detection methods and improved treatments, yet so much remains to be done. With cutting-edge research continually pushing the boundaries of science and discovery, it is not surprising that an increasing number of cancer researchers are turning to the newest tool in the DNA collection toolbox - DNA from saliva.

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Tags: DNA collection, DNA kit, DNA Kits, DNA saliva, saliva DNA, DNA from saliva, genetic disease, cancer genetics, breast cancer, cancer research, DNA sample

Hunting for Cancer Genes with DNA from Saliva

Posted by Shauna White on Tue, Feb 09, 2010 @ 12:02 PM

Every day, it seems, scientists learn something new about how our genes work. One fascinating area of research involves understanding the role of our genes in the initiation, progression and treatment of diseases; such as cancer. Understanding cancer on a molecular and genetic level makes for good science and good medicine. We understand that all cancers are not created equally. From the moment you are conceived, your genes may increase your susceptibility to developing certain cancers or, later on, your environmental exposures or other factors may cause changes in your genes that cause cancer to develop. Cancer is not one disease, but many, adding to the complexity and breadth of studies.

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Tags: DNA collection, genetics, DNA, DNA Kits, DNA saliva, Oragene, DNA from saliva, genetic disease, cancer genetics, breast cancer, cancer research

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This blog is intended to provide information to educate readers about molecular testing and genetic sample collection and DNA Genotek products.  Some of the information on this blog represents emerging scientific research or data developed for research purposes only. More information here.

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Welcome to The Genetic Link, a blog providing new insights into DNA and RNA sample collection by DNA Genotek. DNA Genotek is a subsidiary of OraSure Technologies, Inc.

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