DNA Genotek's Sample Collection Blog

Vitamin D deficiency: the new link to type 2 diabetes mellitus in United Arab Emirates

Posted by Katherine Lawless on Thu, Apr 11, 2019 @ 14:04 PM

“Diabetes is the fastest growing debilitating disease in the world”.

Dr. Al-Anouti and Dr. Al-Safar

In 2015, statistics showed that 415 million people suffer from diabetes worldwide. The rate is expected to increase by 54.5% and reach about 642 million people by 2040.[1] The Middle Eastern population account for approximately 20% of these cases. According to the International Diabetes Federation (IDF), the United Arabian Emirates (UAE) has 745,940 diabetics, 304,000 undiagnosed diabetics, and 934,300 pre-diabetics.3 We corresponded with researchers Dr. Al-Anouti and Dr. Al-Safar from Zayed University and Khalifa University to discuss their research on vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus.  

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Tags: DNA saliva, genetic research, Oragene RNA

Genome-wide DNA methylation comparison: Brain tissue vs. blood, saliva and buccal cells

Posted by Katherine Lawless on Wed, Apr 03, 2019 @ 13:04 PM

DNA methylation (DNAm) has become increasingly widespread in the study of psychiatric disorders.[1] Many psychiatric epigenetic studies began to work with peripheral tissues such as blood and saliva to determine which had the best correlation with brain tissue. Researchers like Smith et al compared the DNA methylation in post-mortem tissue samples with blood and saliva and found there was a higher correlation between the brain and saliva compared to blood - DNA methylation from saliva was about 3% more likely to agree with each area of the brain regions than DNA methylation with blood.1,[2]

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Tags: DNA saliva, Oragene DNA, methylation

Oral swabs for pharmacogenomics: A comparative study of DNA quality and performance

Posted by Katherine Lawless on Tue, Feb 05, 2019 @ 13:02 PM

Pharmacogenomics is a growing field that tailors dosage and drug choices based on patient genetic profiles with the potential to benefit millions of patients with personalized medical care while changing the world of medicine as we know it. One of the key obstacles faced by those working in pharmacogenomics is DNA sample collection. Traditionally, clinicians have used blood samples for DNA collection which are costly (requiring phlebotomy and cold chain logistics) and invasive (hindering patient compliance), making the clinical integration of pharmacogenomics difficult. Many researchers are turning to the idea of buccal and/or saliva swabs as a less costly and non-invasive alternative to DNA collection. However, the question is are these sample types of high enough quality for analysis?

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Tags: DNA saliva, ORAcollect, buccal swabs

8 facts most people don’t know about DNA from saliva

Posted by Scott Rabuka on Fri, Feb 01, 2019 @ 10:02 AM

Since the launch of this blog, The Genetic Link, in 2009, we have published numerous articles, interviews, technical information and infographics to share what we know about DNA from saliva. Saliva is the human body’s most accessible bio-fluid but, after 7 years, we continue to be surprised at how often we hear wrong perceptions about this robust and easy to access sample type.  It’s time to set the record straight on DNA from saliva once and for all. Are you ready? Here are 8 facts about DNA from saliva that most people don’t know.

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Tags: DNA collection, DNA kit, DNA saliva, Oragene, DNA in saliva, genetic testing, genomics, personalized medicine

Exciting discoveries from Spit for Science & a sneak-peak at Spit for Science II

Posted by Erin Carpenter on Tue, Jan 08, 2019 @ 13:01 PM

Russell Schachar, MD, FRCP(C), gave an engaging and inspiring talk at the American Society of Human Genetics (ASHG) conference this year titled: ADHD and OCD genetics: Populations, endophenotypes and quantitative traits. 

The talk featured some of the exciting results gained from the large-scale Spit for Science project. Partnered with the Ontario Science Centre in Toronto, Canada, the Spit for Science project was initiated to accelerate discovery and further understanding of the nature of neurodevelopmental disorders, attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), in children. These types of disorders continue throughout life and can be extremely impairing.

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Tags: DNA saliva, Oragene DNA

Reproductive health and genetic testing: What sample types work best?

Posted by Erin Carpenter on Wed, Dec 05, 2018 @ 13:12 PM

In this blog, we want to discuss the various genetic testing options available with respect to fertility and reproductive health; highlighting the sample collection methods often used to collect DNA. Genetic screening can be used to determine whether a person and/or their partner can successfully conceive a child or whether their infant is at risk to develop certain genetically-based conditions. Genetic risk factors can be passed through the DNA of either one or both parents during conception, and genetic screening helps identify abnormalities in the DNA or chromosomes that may be linked to unwanted health conditions.1 Genetic testing for fertility and reproductive health is being offered by a growing number of commercial companies and can be summarized into four main categories:

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Tags: DNA saliva, ORAcollect, Oragene RNA, human genomics, carrier screening

3 trends within high-impact genomics you may not know about

Posted by Katherine Lawless on Wed, Nov 28, 2018 @ 13:11 PM

Our knowledge of science is constantly changing and improving as new discoveries drive us forward in the modern world. Genomics is no exception. We witness these trends all around us either within the publications we read about new studies, in the news, or perhaps even through blogs such as this one.  For example, I recently attended the American Society of Human Genetics conference in San Diego where I picked up a copy of Cell Press’s Trends Limited Edition High-Impact Genomics, Vol. 3 (link to document) which highlights particularly impactful genomics reviews. It captured my interest and I wanted to share a few highlights with you.

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Tags: DNA saliva, human genomics

Top 5 considerations when selecting a saliva-based DNA collection method

Posted by Kerry Chatburn on Wed, Oct 10, 2018 @ 10:10 AM

The past decade of genetic advancements has proven DNA from saliva is reliable and effective for both research and diagnostics applications.  The benefits of collecting DNA from saliva are clear:

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Tags: DNA collection, DNA Kits, DNA saliva, Oragene, DNA quality

How to execute large-scale DNA sample collection for genetic research - 10 essential considerations

Posted by Kerry Chatburn on Tue, Oct 09, 2018 @ 10:10 AM

Genetic epidemiology, the study of how genetics contribute to health and disease in families and populations, seeks to derive a statistical analysis of how genetics works in large groups. It therefore requires enough DNA samples from a given population to reduce the effect of outliers and ultimately, determine objective truths.  

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Tags: DNA collection, DNA saliva, DNA research

Q&A with Latin American personalized genetics company: Genomit SA (Zoigen)

Posted by Erin Carpenter on Thu, Jul 26, 2018 @ 10:07 AM

Recently DNA Genotek had the pleasure of speaking with MatĂ­as Butti, one of the co-founders of an innovative genomic medicine company located in Argentina named genomIT SA (genomit.com.ar). genomIT SA has a strong and experienced scientific, machine learning & biotechnology team and offers a host of genetic tests under the Zoigen brand, many of which are of their own design. From our discussion, we learned how precision medicine is evolving in Latin America, the challenges the Zoigen brand has encountered while designing and implementing their products and services, as well as how Oragene saliva kits have simplified their collection process.

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Tags: DNA saliva, personalized medicine test, Oragene DNA

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This blog is intended to provide information to educate readers about molecular testing and genetic sample collection and DNA Genotek products.  Some of the information on this blog represents emerging scientific research or data developed for research purposes only. More information here.

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About DNA Genotek

Welcome to The Genetic Link, a blog providing new insights into DNA and RNA sample collection by DNA Genotek. DNA Genotek is a subsidiary of OraSure Technologies, Inc.

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