DNA Genotek's Sample Collection Blog

Oral swabs for pharmacogenomics: A comparative study of DNA quality and performance

Posted by Katherine Lawless on Tue, Feb 05, 2019 @ 13:02 PM

Pharmacogenomics is a growing field that tailors dosage and drug choices based on patient genetic profiles with the potential to benefit millions of patients with personalized medical care while changing the world of medicine as we know it. One of the key obstacles faced by those working in pharmacogenomics is DNA sample collection. Traditionally, clinicians have used blood samples for DNA collection which are costly (requiring phlebotomy and cold chain logistics) and invasive (hindering patient compliance), making the clinical integration of pharmacogenomics difficult. Many researchers are turning to the idea of buccal and/or saliva swabs as a less costly and non-invasive alternative to DNA collection. However, the question is are these sample types of high enough quality for analysis?

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Tags: DNA saliva, ORAcollect, buccal swabs

Exciting discoveries from Spit for Science & a sneak-peak at Spit for Science II

Posted by Erin Carpenter on Tue, Jan 08, 2019 @ 13:01 PM

Russell Schachar, MD, FRCP(C), gave an engaging and inspiring talk at the American Society of Human Genetics (ASHG) conference this year titled: ADHD and OCD genetics: Populations, endophenotypes and quantitative traits. 

The talk featured some of the exciting results gained from the large-scale Spit for Science project. Partnered with the Ontario Science Centre in Toronto, Canada, the Spit for Science project was initiated to accelerate discovery and further understanding of the nature of neurodevelopmental disorders, attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), in children. These types of disorders continue throughout life and can be extremely impairing.

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Tags: DNA saliva, Oragene DNA

Reproductive health and genetic testing: What sample types work best?

Posted by Erin Carpenter on Wed, Dec 05, 2018 @ 13:12 PM

In this blog, we want to discuss the various genetic testing options available with respect to fertility and reproductive health; highlighting the sample collection methods often used to collect DNA. Genetic screening can be used to determine whether a person and/or their partner can successfully conceive a child or whether their infant is at risk to develop certain genetically-based conditions. Genetic risk factors can be passed through the DNA of either one or both parents during conception, and genetic screening helps identify abnormalities in the DNA or chromosomes that may be linked to unwanted health conditions.1 Genetic testing for fertility and reproductive health is being offered by a growing number of commercial companies and can be summarized into four main categories:

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Tags: DNA saliva, ORAcollect, Oragene RNA, human genomics, carrier screening

3 trends within high-impact genomics you may not know about

Posted by Katherine Lawless on Wed, Nov 28, 2018 @ 13:11 PM

Our knowledge of science is constantly changing and improving as new discoveries drive us forward in the modern world. Genomics is no exception. We witness these trends all around us either within the publications we read about new studies, in the news, or perhaps even through blogs such as this one.  For example, I recently attended the American Society of Human Genetics conference in San Diego where I picked up a copy of Cell Press’s Trends Limited Edition High-Impact Genomics, Vol. 3 (link to document) which highlights particularly impactful genomics reviews. It captured my interest and I wanted to share a few highlights with you.

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Tags: DNA saliva, human genomics

Top 5 considerations when selecting a saliva-based DNA collection method

Posted by Kerry Chatburn on Wed, Oct 10, 2018 @ 10:10 AM

The past decade of genetic advancements has proven DNA from saliva is reliable and effective for both research and diagnostics applications.  The benefits of collecting DNA from saliva are clear:

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Tags: DNA collection, DNA Kits, DNA saliva, Oragene, DNA quality

How to execute large-scale DNA sample collection for genetic research - 10 essential considerations

Posted by Kerry Chatburn on Tue, Oct 09, 2018 @ 10:10 AM

Genetic epidemiology, the study of how genetics contribute to health and disease in families and populations, seeks to derive a statistical analysis of how genetics works in large groups. It therefore requires enough DNA samples from a given population to reduce the effect of outliers and ultimately, determine objective truths.  

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Tags: DNA collection, DNA saliva, DNA research

Q&A with Latin American personalized genetics company: Genomit SA (Zoigen)

Posted by Erin Carpenter on Thu, Jul 26, 2018 @ 10:07 AM

Recently DNA Genotek had the pleasure of speaking with Matías Butti, one of the co-founders of an innovative genomic medicine company located in Argentina named genomIT SA (genomit.com.ar). genomIT SA has a strong and experienced scientific, machine learning & biotechnology team and offers a host of genetic tests under the Zoigen brand, many of which are of their own design. From our discussion, we learned how precision medicine is evolving in Latin America, the challenges the Zoigen brand has encountered while designing and implementing their products and services, as well as how Oragene saliva kits have simplified their collection process.

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Tags: DNA saliva, personalized medicine test, Oragene DNA

High quality libraries for human WGS with direct saliva Input

Posted by Erin Carpenter on Thu, Jul 19, 2018 @ 10:07 AM

In the open discussion webinar hosted by Frontline Genomics, Joshua Burgess Ph.D., Manager Scientific Research, R&D at Illumina and Rafal Iwasiow, Ph.D., Vice President, R&D at DNA Genotek explain how the Nextera DNA Flex and Oragene DNA from saliva kits are complementary technologies shifting the paradigm by enabling direct saliva input in the creation of high-quality libraries for whole-genome sequencing (WGS).

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Tags: DNA saliva, whole genome sequencing, Oragene DISCOVER

Comparing minimally invasive sample collection techniques for large population-based telomere length studies

Posted by Erin Carpenter on Thu, Jun 14, 2018 @ 09:06 AM

Telomere length (TL) is a biomarker of age, longevity and age-related disease. If you are an avid follower of our blog, The Genetic Link, you’ll notice that we’ve posted about TL previously (you can find the links here and here), because we find this area of research fascinating.

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Tags: DNA collection, DNA saliva, Oragene, telomere

Obesity, Hypertension and Cardiovascular Risk in Italian Youth

Posted by Erin Carpenter on Thu, May 24, 2018 @ 09:05 AM

Cardiovascular disease (CVD) is a very serious and life-threatening condition. Hypertension (HT) is a significant risk factor contributing to CVD, and also one that may be detected early and controlled; thus, reducing CVD-mediated mortality and morbidity. Recently, the growing trend of adolescent obesity has predisposed youth to both HT and CVD, and has become a serious health concern within the population. Obesity appears to have both genetic and environmental/nutritional factors, and given the risk to health, merits dedicated research to understand and, hopefully, combat it.

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Tags: DNA collection, DNA saliva, Oragene, genetic research

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This blog is intended to provide information to educate readers about molecular testing and genetic sample collection and DNA Genotek products.  Some of the information on this blog represents emerging scientific research or data developed for research purposes only. More information here.

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About DNA Genotek

Welcome to The Genetic Link, a blog providing new insights into DNA and RNA sample collection by DNA Genotek. DNA Genotek is a subsidiary of OraSure Technologies, Inc.

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