This month, PLoS ONE published a new research study that I think will interest readers of The Genetic Link. The study, titled "Array-Based Whole-Genome Survey of Dog Saliva DNA Yields High Quality SNP Data", was written by Jennifer S. Yokoyama, Carolyn A. Erdman and Steven P. Hamilton of the Department of Psychiatry and Institute for Human Genetics, at the University of California, San Francisco. The study is interesting for several reasons.
DNA Genotek's Sample Collection Blog
Oragene is well known for a number of characteristics - ease of use, non-invasive collection, high quality and quantity DNA and, of course, long term storage at ambient temperature. It's often difficult for researchers and clinicians to believe that storage at ambient temperature is possible for DNA samples. We are frequently asked about this specification of our product. However, studies using Oragene prove that customers can rely on the ability to store Oragene/saliva samples at ambient temperatures when collecting samples in remote locations, via the mail, or for event-based recruitment. The figure to the right shows an agarose gel electrophoresis of DNA extracted from Oragene/saliva samples stored at room temperature for years.
Today, DNA Genotek announced our involvement in a significant pilot project with the UK's largest bone marrow registry, the Anthony Nolan Trust. The details of this exciting project follow:
DNA Genotek, a leading provider of products for biological sample collection, stabilization and preparation, today announced that The Anthony Nolan Trust, the UK's largest bone marrow donor registry, has selected Oragene•DNA for a pilot project aimed at increasing donor recruitment. Bone marrow donor registries, also known as HLA registries, use HLA DNA testing to match leukemia patients with prospective donors. The pilot project will determine if donor recruitment can be increased significantly with the use of non-invasive, saliva-based DNA collection compared to blood collection.
At the department of Anthropology and Genetics Institute at the University of Florida, we study genetic variation in modern human populations to answer diverse questions ranging from the route early humans took when they first migrated out of Africa to the underlying causes of racial differences in susceptibility to complex diseases. To explore these varied aspects of human evolutionary history, we spend a lot of time figuring out how to collect DNA from a large number of volunteers. With today's genetic technology, all that's necessary is to obtain a small blood or saliva sample from each of our participants -- a task relatively easy to do in concept but quite a bit more challenging in practice.
DNA Day commemorates the successful completion of the Human Genome Project in 2003 and the discovery of DNA's double helix by Watson and Crick in 1953. The Human Genome Project was a 13-year project coordinated by the U.S. Department of Energy and the National Institutes of Health. The primary goal of the project was to determine the sequence of chemical base pairs which make up DNA and to identify the approximately 20,000-25,000 genes of the human genome. As a result of the Human Genome Project, a Congressional resolution designated April 23 as the National DNA Day.
For the second year in a row, DNA Genotek collected DNA samples onsite at the National Walk for Epilepsy on March 27th, 2010 in Washington, DC. Our participation in this event supports the efforts of the Columbia University Family Studies in Epilepsy Program and their study which is designed to identify genes that play a role in causing epilepsy. While at the Epilepsy Walk, I had the opportunity to interview Janine Rose, Research Associate at Columbia University about their epilepsy research and how Oragene•DNA has helped their study. You can view the recorded interview here or read the transcript below.
Today, DNA Genotek announced that our Oragene•DNA self collection kit (OG-500), has been selected as a winner in the 2010 Medical Design Excellence Awards (MDEA) competition, the premier awards program for the medical technology community.
Saliva is one of the most accessible of our body's bio-fluids making saliva sample collection easy and non-invasive. Saliva also harbours a wide spectrum of genetic data that can be used for genetic research and clinical diagnostic applications. It might surprise you to know that much confusion surrounds the source of genomic DNA in saliva. It certainly came as a surprise to me when I met with a number of customers on a recent trip across the continent.
For the second year in a row, DNA Genotek will be collecting DNA samples onsite at the National Walk for Epilepsy on March 27th, 2010 in Washington, DC. Our participation in this event supports the efforts of the Columbia University Family Studies in Epilepsy Program and their study which is designed to identify genes that play a role in causing epilepsy.
This morning, BioServe Biotechnologies announced that they have completed validation testing of the Oragene/saliva collection kits and have joined DNA Genotek's Partner Program. Now, BioServe can offer customers a comprehensive testing platform for extraction and genetic analysis for Oragene/saliva samples. BioServe has validated Oragene kits for use within its DNA extraction and genotyping service, including sample quantification and normalization; whole genome amplification; multiplex-based genotyping, expression analysis and sample archiving.