My lab is devoted to understanding the biological and psychological characteristics of persons at risk for alcoholism. Alcohol addiction is a behavioral disorder with both genetic and environmental contributions. Persons with a positive family history of alcoholism are 4 – 6 times as likely to develop an alcohol use disorder as persons with no such history. Our guiding hypothesis is that a genetic predisposition toward alcohol and other substance-use disorders involves altered function of brain regions regulating reward motivation. We are studying four domains of function related to prefrontal cortex and limbic system regulation of motivated behavior: 1) Behavioral under control: the person's temperamental balance of positive to negative affect should be less stable and weighted toward dysphoria. 2) Cognitive processing on tests or working memory. 3) Decision-making during a reward based delay discounting calling for choices between immediate, but small rewards vs. waiting over a time delay to gain a larger reward. 4) Visceral responses to psychological stress using the stress hormone, cortisol, and autonomic control of the heart.
DNA Genotek's Sample Collection Blog
Last week, at the American Society for Human Genetics show in Washington, DC, several members of the DNA Genotek team presented posters reflecting new research findings. ASHG is an event that brings together over 5000 delegates from all areas of genetic research and is well known for encouraging and integrating research, scholarship and education in all areas of human genetics. We used this opportunity to showcase new research findings and technical evaluations for the Oragene family of products.
I have to admit, coming up with DNA Genotek's "Top 10 list for 2009" was more difficult than I imagined it would be. There are so many great things that happened in the past year - in our company, with our customers, and in the field of genetics - but I think I've narrowed it down to those that are most significant.
Tags: Oragene, DNA collection, DNA from animals, DNA, DNA testing, genetic testing, genetic disease, DNA saliva, DNA dog kit, DNA kit, Kaiser Permanente, DNA Kits, genotyping, tropical disease, Genome wide association studies, GWAS, genome mapping