DNA Genotek's Sample Collection Blog

Genome-wide DNA methylation comparison: Brain tissue vs. blood, saliva and buccal cells

Posted by Katherine Lawless on Wed, Apr 03, 2019 @ 13:04 PM

DNA methylation (DNAm) has become increasingly widespread in the study of psychiatric disorders.[1] Many psychiatric epigenetic studies began to work with peripheral tissues such as blood and saliva to determine which had the best correlation with brain tissue. Researchers like Smith et al compared the DNA methylation in post-mortem tissue samples with blood and saliva and found there was a higher correlation between the brain and saliva compared to blood - DNA methylation from saliva was about 3% more likely to agree with each area of the brain regions than DNA methylation with blood.1,[2]

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Tags: DNA saliva, Oragene DNA, methylation

All about that base: applications of the fifth base of DNA

Posted by Lisa Gamwell on Tue, May 12, 2015 @ 13:05 PM

Methylated cytosine, also known as “the fifth base of DNA” has attracted a lot of research attention lately due to its importance in controlling gene expression. This fifth base has inspired researchers to study its impact on several diverse fields, such as oncology, neurology, psychology, forensics and even workplace health and safety. Methylated cytosine has even been used as a predictor of biological age [1].In this blog post I’d like to share a few examples of the exciting ways this “extra” base is providing new avenues for research. 

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Tags: DNA collection, DNA saliva, methylation

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This blog is intended to provide information to educate readers about molecular testing and genetic sample collection and DNA Genotek products.  Some of the information on this blog represents emerging scientific research or data developed for research purposes only. More information here.

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Welcome to The Genetic Link, a blog providing new insights into DNA and RNA sample collection by DNA Genotek. DNA Genotek is a subsidiary of OraSure Technologies, Inc.

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