DNA methylation (DNAm) has become increasingly widespread in the study of psychiatric disorders. Many psychiatric epigenetic studies began to work with peripheral tissues such as blood and saliva to determine which had the best correlation with brain tissue. Researchers like Smith et al compared the DNA methylation in post-mortem tissue samples with blood and saliva and found there was a higher correlation between the brain and saliva compared to blood - DNA methylation from saliva was about 3% more likely to agree with each area of the brain regions than DNA methylation with blood.1,Read More
DNA Genotek's Sample Collection Blog
Russell Schachar, MD, FRCP(C), gave an engaging and inspiring talk at the American Society of Human Genetics (ASHG) conference this year titled: ADHD and OCD genetics: Populations, endophenotypes and quantitative traits.
The talk featured some of the exciting results gained from the large-scale Spit for Science project. Partnered with the Ontario Science Centre in Toronto, Canada, the Spit for Science project was initiated to accelerate discovery and further understanding of the nature of neurodevelopmental disorders, attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), in children. These types of disorders continue throughout life and can be extremely impairing.Read More
Recently DNA Genotek had the pleasure of speaking with Matías Butti, one of the co-founders of an innovative genomic medicine company located in Argentina named genomIT SA (genomit.com.ar). genomIT SA has a strong and experienced scientific, machine learning & biotechnology team and offers a host of genetic tests under the Zoigen brand, many of which are of their own design. From our discussion, we learned how precision medicine is evolving in Latin America, the challenges the Zoigen brand has encountered while designing and implementing their products and services, as well as how Oragene saliva kits have simplified their collection process.Read More
World Health Day (April 7th) falls within this month, and to celebrate we thought it would be fun to countdown the top 6 genetic innovations that we feel have the potential to improve human health in a two-part series. For everyone directly involved in the field of science, novel discoveries are the norm. Researchers continue to build on previous discoveries, pushing the boundaries of our known world further every day. It is refreshing to take a step back and realize how profound some of these discoveries truly are. Only a generation ago the genetic realities of today were the incredible stories found within the pages of sci-fi comic books! Not anymore. Here are our first 3:Read More
We would like to introduce you to Oragene•DISCOVER, a new brand for our research customers within the United States. Oragene•DISCOVER is the result of a change in the brand name and labeling of our Oragene•DNA product. Here are some of the reasons why we made this change and what we think it means for you.
We are all familiar with the role genetics play in shaping our physical appearance. You might have inherited your mother’s green eyes or your father’s broad shoulders. We too understand how genes influence our risk or resilience to developing various conditions. In previous The Genetic Link blog features we’ve linked genes with substance abuse, cancer, epilepsy and tropical diseases. But what I’ve been pondering lately is how and to what extent our unique genetic code is involved in making us who we are by shaping our personality, behavior, social interactions and thought processes. Perhaps you’re familiar with the idea of nature versus nurture, or gene versus environment studies. What I want to know is how much of who I am is due to my genetic make-up versus how much is a result of that complicated mix of my early experiences, social and cultural influences, family interactions, education…in other words, my environment? These almost philosophical questions are tackled on a daily basis by psychologists, psychiatrists and neurologists; and I am absolutely riveted by this research.
In the past year, The Genetic Link has explored how genetics is linked to disease, drug response, bone marrow transplants, and even weight loss. I am constantly amazed at the number of new discoveries that link our genes to different aspects of our lives. This past month, I was surprised once again. I recently had the pleasure of speaking with a researcher who is doing some novel work in an area that most people would not associate with genetic research.
Oragene is well known for a number of characteristics - ease of use, non-invasive collection, high quality and quantity DNA and, of course, long term storage at ambient temperature. It's often difficult for researchers and clinicians to believe that storage at ambient temperature is possible for DNA samples. We are frequently asked about this specification of our product. However, studies using Oragene prove that customers can rely on the ability to store Oragene/saliva samples at ambient temperatures when collecting samples in remote locations, via the mail, or for event-based recruitment. The figure to the right shows an agarose gel electrophoresis of DNA extracted from Oragene/saliva samples stored at room temperature for years.
Today, DNA Genotek announced our involvement in a significant pilot project with the UK's largest bone marrow registry, the Anthony Nolan Trust. The details of this exciting project follow:
DNA Genotek, a leading provider of products for biological sample collection, stabilization and preparation, today announced that The Anthony Nolan Trust, the UK's largest bone marrow donor registry, has selected Oragene•DNA for a pilot project aimed at increasing donor recruitment. Bone marrow donor registries, also known as HLA registries, use HLA DNA testing to match leukemia patients with prospective donors. The pilot project will determine if donor recruitment can be increased significantly with the use of non-invasive, saliva-based DNA collection compared to blood collection.
At the department of Anthropology and Genetics Institute at the University of Florida, we study genetic variation in modern human populations to answer diverse questions ranging from the route early humans took when they first migrated out of Africa to the underlying causes of racial differences in susceptibility to complex diseases. To explore these varied aspects of human evolutionary history, we spend a lot of time figuring out how to collect DNA from a large number of volunteers. With today's genetic technology, all that's necessary is to obtain a small blood or saliva sample from each of our participants -- a task relatively easy to do in concept but quite a bit more challenging in practice.