A fascinating area of research that has been gaining a lot of momentum concerns the influence of our microbiome with overall health and disease. The human microbiome encompasses the totality of microbes, their genetic elements and their environment. Studies have shown an association between the human oral microbiota and risk of chronic diseases, such as cardiovascular disease, diabetes, obesity and certain cancers. There are many factors that influence microbial populations, such as dietary factors, exposure to pathogenic organisms and overall health status. The relationship between the host and its resident commensal and pathogenic organisms is complex and dynamic; and an exciting area of science with so much yet to be discovered.