My lab is devoted to understanding the biological and psychological characteristics of persons at risk for alcoholism. Alcohol addiction is a behavioral disorder with both genetic and environmental contributions. Persons with a positive family history of alcoholism are 4 – 6 times as likely to develop an alcohol use disorder as persons with no such history. Our guiding hypothesis is that a genetic predisposition toward alcohol and other substance-use disorders involves altered function of brain regions regulating reward motivation. We are studying four domains of function related to prefrontal cortex and limbic system regulation of motivated behavior: 1) Behavioral under control: the person's temperamental balance of positive to negative affect should be less stable and weighted toward dysphoria. 2) Cognitive processing on tests or working memory. 3) Decision-making during a reward based delay discounting calling for choices between immediate, but small rewards vs. waiting over a time delay to gain a larger reward. 4) Visceral responses to psychological stress using the stress hormone, cortisol, and autonomic control of the heart.
DNA Genotek's Sample Collection Blog
Many of you are probably aware that the American Society for Human Genetics Conference (ASHG) is happening this week in Washington, DC. It’s an event that brings together over 5000 delegates from all areas of genetic research and is well known for encouraging and integrating research, scholarship and education in all areas of human genetics. It has become one of DNA Genotek’s favorite annual events. This year, we have organized so many events at the ASHG conference that I thought we’d summarize everything here in The Genetic Link.
For any type of genetic analysis (e.g. population studies, clinical genetic testing, paternity testing, pharmacogenomic testing), non-invasive and easy-to-use sample collection techniques are preferred because they increase compliance rates and reduce costs. Oragene•DNA is a DNA self-collection kit that is completely non-invasive, intuitive to use, and stabilizes DNA at elevated temperatures which facilitates transport and storage by eliminating the need for refrigeration.
If you've been following our blog or our newsletter, you're probably aware that DNA Genotek has experienced significant growth in our partner program. We've added partners across all categories: genomics service providers, diagnostic service providers and technology vendors.
Beckman Coulter Genomics has developed a new version of their DNAdvance System specifically for use with DNA Genotek’s Oragene samples. DNAdvance SP, from Beckman Coulter Genomics, is an extraction kit for the isolation and purification of DNA from saliva samples collected with Oragene self-collection Kits. The high throughput genomic DNA (gDNA) isolation reagent system enables the purification of high quality DNA from saliva samples, making it ideal for genotyping applications (SNP, fragment analysis), sequencing and qPCR. The system provides researchers and laboratories with an optimized and robust solution for DNA extraction and purification from saliva collected with Oragene kits.
This morning, Clinical Reference Laboratory (CRL) announced that it has completed validation testing of DNA Genotek's Oragene/saliva collection kits and will adopt Oragene for use with its molecular diagnostic services.
At the 2010 Plant and Animal Genome Conference in San Diego, DNA Genotek officially launched our newest sample collection product called Performagene•LIVESTOCK. Performagene•LIVESTOCK, a simple and easy-to-use nasal collection device for cattle, sheep and swine, provides high quality and high quantity DNA that remains stable at ambient temperatures.
Tags: DNA collection, genetics, DNA, DNA testing, DNA kit, DNA Kits, livestock genetics, performagene, livestock dna, livestock industry, Oragene, genetic testing, genotyping, SNP, Single Nucleotide Polymorphism, genomics, microarray, microsattelite