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Is there a new gold-standard for gut microbiome stool collection?

The “gold standard” for gut microbiome studies has traditionally been a fresh stool sample that was immediately processed or immediately frozen at -20ºC or -80ºC. However in ...
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PREdiCCt: the largest study on predicting IBD disease flare

This week, I interviewed Dr. Charlie Lees and Lee Murphy, investigators for the PREdiCCt Study (Prognostic effect of environmental factors in Crohn’s and Colitis). PREdiCCt is ...
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Cold chain stool sample collection: A series of unfortunate events (Part 3/3)

Throughout our cold chain stool sample collection series we explored the challenges, high cost, and low quality results that often come with shipping stool samples via cold ...
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Sequencing the microbiome: Are you getting the full story?

Evolution of sequencing technology Since the human genome was sequenced and famously published in Nature and Science in 2001(1)(2), sequencing technology has experienced ...
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Cold chain stool sample collection: A series of unfortunate events (part 2/3)

Most people consider the nature of collecting fecal samples unpleasant and inconvenient. One of the challenges for the researcher conducting a gut microbiome study, is to ...
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Cold chain stool sample collection: a series of unfortunate events (Part 1/3)

In this first of a three-part blog series, I am delving into the topic of cold-chain stool collection and transportation. I will explore the challenges of collection and ...
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Choosing the best DNA extraction method in human gut microbiome community profiling

A critical component to any human gut microbiome study is the ability to accurately represent the ‘true’ microbial community present at a specific period in time or, in other ...
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The importance of quality pre-analytical factors and their impact on microbiome analysis

Since the completion of the Human Microbiome Project (HMP), the number of microbiome focused research programs, peer-reviewed publications and patents has grown exponentially. ...
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Microbiome learnings from the Weizmann Institute

Update: Since this interview with the Weizmann Institute, the results of the Personalized Nutrition Project have been published in the journal Cell: “Personalized Nutrition by ...
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