DNA Genotek's Sample Collection Blog

Urine as a liquid biopsy for cancer detection – Could yellow be the new red?

Posted by Kerry Chatburn on Wed, Apr 24, 2019 @ 13:04 PM

I recently had the opportunity to visit our new sister company, Novosanis+ in Antwerp, Belgium, to talk about urine as a sample type. Novosanis is dedicated to solving urine sampling challenges through its product Colli-Pee™ - an award-winning device designed to efficiently and hygienically capture first-void urine (the first 20ml of a urine sample). 

I spoke with CEO and co-founder, Vanessa Vankerckhoven. You may also listen to our full interview on our podcast: Molecules, Microbes and Multiomics.  

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Tags: Collipee, urine collection, cancer detection urine

Vitamin D deficiency: the new link to type 2 diabetes mellitus in United Arab Emirates

Posted by Katherine Lawless on Thu, Apr 11, 2019 @ 14:04 PM

“Diabetes is the fastest growing debilitating disease in the world”.

Dr. Al-Anouti and Dr. Al-Safar

In 2015, statistics showed that 415 million people suffer from diabetes worldwide. The rate is expected to increase by 54.5% and reach about 642 million people by 2040.[1] The Middle Eastern population account for approximately 20% of these cases. According to the International Diabetes Federation (IDF), the United Arabian Emirates (UAE) has 745,940 diabetics, 304,000 undiagnosed diabetics, and 934,300 pre-diabetics.3 We corresponded with researchers Dr. Al-Anouti and Dr. Al-Safar from Zayed University and Khalifa University to discuss their research on vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus.  

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Tags: DNA saliva, genetic research, Oragene RNA

Genome-wide DNA methylation comparison: Brain tissue vs. blood, saliva and buccal cells

Posted by Katherine Lawless on Wed, Apr 03, 2019 @ 13:04 PM

DNA methylation (DNAm) has become increasingly widespread in the study of psychiatric disorders.[1] Many psychiatric epigenetic studies began to work with peripheral tissues such as blood and saliva to determine which had the best correlation with brain tissue. Researchers like Smith et al compared the DNA methylation in post-mortem tissue samples with blood and saliva and found there was a higher correlation between the brain and saliva compared to blood - DNA methylation from saliva was about 3% more likely to agree with each area of the brain regions than DNA methylation with blood.1,[2]

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Tags: DNA saliva, Oragene DNA, methylation

Considering adding microbiome to your research? Thoughts from Dr. Dan Knights

Posted by Shauna White on Wed, Mar 27, 2019 @ 13:03 PM

We recently introduced readers of The Microbiome Snapshot to our sister company, CoreBiome, a privately-held, Minnesota-based microbiome analysis company that accelerates discovery for customers in the pharmaceutical, agricultural, environmental and research communities. We are continuing this story via a podcast with CoreBiome co-founder, Dr. Dan Knights. In this new podcast, Dr. Knights speaks to us about why the microbiome is so different from the human genome, what answers microbiome research can provide for wellness and disease that we can’t find elsewhere, and what advice he would give an epidemiologist who is looking to add a microbiome component to their project.

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Tags: microbiome sample collection, microbiome extraction, microbiome analysis, shotgun sequencing

Celebrating influential women in genetics - International women's day

Posted by Katherine Lawless on Fri, Mar 08, 2019 @ 08:03 AM

Throughout history, women have influenced and shaped our views and knowledge of science from all disciplines, including human genomics. The research of radioactivity by Dr. Marie Curie (1867-1934), the discovery of the XY sex-determination system by Dr. Nettie Maria Stevens (1861-1912), and the co-discovery of the genetic material of life by Dr. Martha Chase (1927-2003), has shaped genomics and the influence of incredible women like these is undeniable.[1] In addition, many feel that much of the credit for modeling the structure of the DNA molecule should rightfully go to a woman named Rosalind Franklin and not Watson and Crick. These women have brought their love of genetics to life and shared their scientific discoveries with the world.

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Tags: genetic research, human genomics

Is whole genome sequencing the new first-line test for children with genetic diseases?

Posted by Katherine Lawless on Tue, Feb 19, 2019 @ 13:02 PM

Congenital anomalies and genetic disorders are the leading cause of death in children less than ten years old and affect about six percent of live births. For children with suspected genetic disorders, it is crucial to establish an early etiologic diagnosis for a prompt implementation of precision medicine and to enable optimal outcomes to guide clinical decisions. The challenge, however, is the lack of etiologic diagnosis.

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Tags: whole genome sequencing, DNA saliva cost, Oragene RNA

Oral swabs for pharmacogenomics: A comparative study of DNA quality and performance

Posted by Katherine Lawless on Tue, Feb 05, 2019 @ 13:02 PM

Pharmacogenomics is a growing field that tailors dosage and drug choices based on patient genetic profiles with the potential to benefit millions of patients with personalized medical care while changing the world of medicine as we know it. One of the key obstacles faced by those working in pharmacogenomics is DNA sample collection. Traditionally, clinicians have used blood samples for DNA collection which are costly (requiring phlebotomy and cold chain logistics) and invasive (hindering patient compliance), making the clinical integration of pharmacogenomics difficult. Many researchers are turning to the idea of buccal and/or saliva swabs as a less costly and non-invasive alternative to DNA collection. However, the question is are these sample types of high enough quality for analysis?

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Tags: DNA saliva, ORAcollect, buccal swabs

8 facts most people don’t know about DNA from saliva

Posted by Scott Rabuka on Fri, Feb 01, 2019 @ 10:02 AM

Since the launch of this blog, The Genetic Link, in 2009, we have published numerous articles, interviews, technical information and infographics to share what we know about DNA from saliva. Saliva is the human body’s most accessible bio-fluid but, after 7 years, we continue to be surprised at how often we hear wrong perceptions about this robust and easy to access sample type.  It’s time to set the record straight on DNA from saliva once and for all. Are you ready? Here are 8 facts about DNA from saliva that most people don’t know.

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Tags: DNA collection, DNA kit, DNA saliva, Oragene, DNA in saliva, genetic testing, genomics, personalized medicine

DNA Genotek’s top 10 list for 2018

Posted by Brian Smith on Mon, Jan 21, 2019 @ 13:01 PM

Every year since 2009 we’ve picked our top 10 list for the year. People often ask, what does it take to get on this list? It’s a reasonable question — some of our previous picks haven’t yet reached widespread use, while others may be on the cusp of becoming widely adopted. What we’re really highlighting is something that we think has the potential to have either a long term or profound effect on our lives. We aren’t always right but we find it interesting to reflect on the previous year and highlight our top 10 items.

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Tags: Oragene, personalized medicine, OMNIgene, DNA saliva cost, gut microbiome research, human genomics

Exciting discoveries from Spit for Science & a sneak-peak at Spit for Science II

Posted by Erin Carpenter on Tue, Jan 08, 2019 @ 13:01 PM

Russell Schachar, MD, FRCP(C), gave an engaging and inspiring talk at the American Society of Human Genetics (ASHG) conference this year titled: ADHD and OCD genetics: Populations, endophenotypes and quantitative traits. 

The talk featured some of the exciting results gained from the large-scale Spit for Science project. Partnered with the Ontario Science Centre in Toronto, Canada, the Spit for Science project was initiated to accelerate discovery and further understanding of the nature of neurodevelopmental disorders, attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), in children. These types of disorders continue throughout life and can be extremely impairing.

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Tags: DNA saliva, Oragene DNA

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This blog is intended to provide information to educate readers about molecular testing and genetic sample collection and DNA Genotek products.  Some of the information on this blog represents emerging scientific research or data developed for research purposes only. More information here.

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About DNA Genotek

Welcome to The Genetic Link, a blog providing new insights into DNA and RNA sample collection by DNA Genotek. DNA Genotek is a subsidiary of OraSure Technologies, Inc.

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